Two vehicles crashed on the A151 Isle of Ely Way on Sunday.
Crews from March and Chatteris were called out after the two vehicles collided and landed in a ditch at 1.20am.
One casualty was released before the arrival of the fire service.
Firefighters used stabilising and cutting equipment to release one casualty. Both casualties were taken to hospital by ambulance.
Crews returned to their stations by 3.20am.