A flood warning is in place at Welney and the A1101 is currently closed due to flooding.
The Wash Road, between Welney and Suspension Bridge is regularly closed during the winter months due to rising water in the Ouse Washes.
It was closed over the weekend, with more rain expected today (Monday) and tomorrow.
The Environment Agency has issued an amber flood warning, which alerts people in affected areas to possible flooding and tells them to be prepared.
Up to 30cm of water is anticipated on the low-lying road from Welney.