Wisbech hoped for back to back wins in Eastern Counties 1 for the first time this year.
They started positively with De la Rey Veenendaal making 50 metres and going over from the first play.
Wisbech soon found themselves behind to two penalties. Wisbech scored a further try via James Napier. Jack Malkin kicked a further penalty before half-time. A lack of concentration and poor defence resulted in Wymondham scoring a try.
The second half began with further poor discipline around the ruck and ineffectiveness at scrum time. This led to three Wymondham tries whilst winger Arturas Rudys was sin binned for a deliberate knock down and Solomon Prestidge for tackling the man without the ball.
Wymondham also had two players sin-binned either side of half time but Wisbech failed to capitalise on this. Raimondas Vinksna scored but Wisbech failed to display set piece dominance or aggression in the tackle.
David Wadsley on his first return since a year had a strong performance but the man-of-the match went to De la Rey Veenendaal.
“This is a very close league. We need to learn how to win and not just be satisfied with giving it a good go,” said captain Sol Prestidge.
Wisbech host Ipswich on Saturday in a must-win game with Wisbech at the bottom end of the table.